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Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou
《医学前沿(英文)》 2011年 第5卷 第2期 页码 163-170 doi: 10.1007/s11684-011-0143-9
关键词: Chinese medicine experience medicine evidence-based medicine real world
Guangbiao Zhou, Saijuan Chen, Zhu Chen
《医学前沿(英文)》 2020年 第14卷 第2期 页码 117-125 doi: 10.1007/s11684-020-0773-x
关键词: COVID-19 SARS-CoV-2 pathogenesis evidence-based medicine control and therapeutic strategies
Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine
Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu
《医学前沿(英文)》 2011年 第5卷 第2期 页码 157-162 doi: 10.1007/s11684-011-0128-8
关键词: evidence-based medicine clinical pathway methodology concept technical difficulty
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19
《医学前沿(英文)》 doi: 10.1007/s11684-023-1040-8
关键词: traditional Chinese medicine COVID-19 SARS-CoV-2 clinical evidence-based study mechanism integrated traditional Chinese and Western medicine
传统中医药治疗类风湿性关节炎——从经验医学到循证医学 Review
潘胡丹, 肖瑶, 王婉莹, 任汝通, 梁丽娴 , 刘良
《工程(英文)》 2019年 第5卷 第5期 页码 895-906 doi: 10.1016/j.eng.2019.01.018
类风湿关节炎(RA)是一种常见的自身免疫性疾病,病因难以捉摸。常规和生物疾病缓解药物有时会失效或仅产生部分反应。中药(TCM)长期以来一直在中国用作RA的治疗方法,并在世界范围内得到越来越多的接受。传统上,中医治疗以中医辨证论治为指导。但是,它们仍然依赖于中医理论和医生进行经验实践
关键词: 中药,类风湿关节炎,循证治疗,展望
Translating evidence into policy in China: opportunities and challenges
Jiyao Wang, Xuejuan Jin
《医学前沿(英文)》 2011年 第5卷 第3期 页码 315-320 doi: 10.1007/s11684-011-0146-6
关键词: clinical epidemiology evidence-based decision making policy
Clinical research of traditional Chinese medicine in big data era
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《医学前沿(英文)》 2014年 第8卷 第3期 页码 321-327 doi: 10.1007/s11684-014-0370-y
With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.
关键词: big data traditional Chinese medicine clinical evaluation evidence based medicine
王聪慧,冯哲,尹智炜,李爽,陈香美
《中国工程科学》 2021年 第23卷 第2期 页码 169-174 doi: 10.15302/J-SSCAE-2021.02.016
新型冠状病毒肺炎( COVID-19)疫情席卷全球,中西医结合医学作为我国特有的医学模式,在抗击疫情过程中发挥了重要作用;及时总结运用经验,提升中西医结合医学事业发展水平,将为我国全民健康与医药卫生事业发展提供坚实保障。本文利用文献分析、问卷调查等方法获得的基础数据,梳理了新中国成立以来中西医结合取得的基础成绩,总结了中西医结合医学在 COVID-19 疫情防控方面发挥的关键作用;在梳理发展现状的基础上,研判了中西医结合在医疗资源、临床教育科研、国际化等方面存在的不足。研究提出了实现中西医结合继承创新、引领世界传统医药与现代医学结合发展等我国新形势下中西医结合医学的建设目标;据此建议,完善中西医结合治理体系,加强中西医结合防治人才和队伍建设,积极推动中西医结合国际交流发展,弘扬中西医结合文化。
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《医学前沿(英文)》 2015年 第9卷 第4期 页码 457-467 doi: 10.1007/s11684-015-0417-8
Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin (heavy metals, pesticides, and mycotoxins) contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.
关键词: drug-induced liver injury pharmacognosy metabolomics stilbene Polygonum multiflorum Chinese herbal medicine
Multi-stage emergency medicine logistics system optimization based on survival probability
Ke WANG, Yixin LIANG, Lindu ZHAO
《工程管理前沿(英文)》 2017年 第4卷 第2期 页码 221-228 doi: 10.15302/J-FEM-2017020
关键词: emergency medicine logistics ambulance drone survival probability critical illness
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿(英文)》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
《医学前沿(英文)》 2022年 第16卷 第5期 页码 736-744 doi: 10.1007/s11684-021-0870-5
关键词: pneumoconiosis randomized controlled trials traditional Chinese medicine
Genetic evidence in planar cell polarity signaling pathway in human neural tube defects
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 68-78 doi: 10.1007/s11684-014-0308-4
Neural tube defects (NTDs) are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.
关键词: planar cell polarity neural tube defects rare mutations
From SARS to MERS: evidence and speculation
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 377-382 doi: 10.1007/s11684-016-0466-7
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths. Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.
关键词: middle east respiratory syndrome animal origin cross-species transmission monoclonal antibody
标题 作者 时间 类型 操作
Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine
Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou
期刊论文
Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies
Guangbiao Zhou, Saijuan Chen, Zhu Chen
期刊论文
Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine
Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu
期刊论文
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19
期刊论文
Translating evidence into policy in China: opportunities and challenges
Jiyao Wang, Xuejuan Jin
期刊论文
Ulrike Lindequist:蕈菌治疗学的循证之路(2019年9月19日)
Ulrike Lindequist(高级职称)
2021年01月20日
会议视频
Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known
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期刊论文
Multi-stage emergency medicine logistics system optimization based on survival probability
Ke WANG, Yixin LIANG, Lindu ZHAO
期刊论文
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients
期刊论文